publications

A summary of my publication. See my Google Scholar profile for the most up to date list.

2026

  1. CBR-db: A Cheminformatic Database for Biochemical Reaction Analysis
    Louie Slocombe, C Millsaps, M R Shahjahan, K Narasimhan, and Sara Imari Walker
    ACS Synthetic Biology, 2026
    DOI
  2. Assembly Spaces: Formal Definitions and Fast Methods for Approximating Assembly Indices
    G Siebert, R Chowdhury, Louie Slocombe, and Sara Imari Walker
    arXiv preprint arXiv:2606.15499, 2026
    arXiv
  3. Deep-time Consistency in Proteome Elemental Composition Across Cellular and Viral Life
    L F Benites, Louie Slocombe, and Sara Imari Walker
    arXiv preprint arXiv:2605.19333, 2026
    arXiv
  4. Searching for Life-As-We-Don’t-Know-It: Mission-relevant Application of Assembly Theory for Exoplanet Life Detection
    Sara Imari Walker, E Janin, E Shkolnik, Louie Slocombe, and L Cronin
    arXiv preprint arXiv:2603.11086, 2026
    Habitable Worlds Observatory RFI white paper
    arXiv
  5. Quantifying Complexity and Recursivity in Chemistry and Beyond: AssemblyTheoryTools
    Louie Slocombe, G Siebert, E Janin, J Fedrow, V Mierzejewski, M Shahjahan, M Fernandez-Ruz, S Pagel, I Seet, K Patarroyo, and 3 more authors
    Nature Protocols, 2026
    Under consideration

2025

  1. Understanding water behaviour on 2D material interfaces through single-molecule motion on h-BN and graphene
    Phillip Seiler, Anthony JR Payne, Neubi F Xavier Jr, Louie Slocombe, Marco Sacchi, and Anton Tamtögl
    Nature communications, 2025
  2. Computational Insight into the Intercalating Properties of Cryptolepine
    George Ferguson, Louie Slocombe, John Lisgarten, David Lisgarten, Colin William Wright, Rosemary Talbert, Rex A Palmer, Brendan James Howlin, and Marco Sacchi
    ACS omega, 2025
  3. Proton transfer in methylated G–C: nuclear quantum effects and water-assisted hopping
    Juliana G Abrantes, Adam P Motala, Ian Riddlestone, Louie Slocombe, and Marco Sacchi
    Physical chemistry chemical physics, 2025
  4. The Emergence of Chirality from Metabolism
    J F Malloy, C Millsaps, K Narasimhan, Louie Slocombe, C Mathis, L Cronin, and Sara Imari Walker
    Nature Communications, 2025
    Accepted; preprint available as arXiv:2505.01056
    arXiv
  5. Searching for Life as We Don’t Know It: Detecting Signatures of Chemical Selection in Exoplanet Atmospheres
    E Janin, E Shkolnik, Louie Slocombe, and Sara Imari Walker
    In 246th Meeting of the American Astronomical Society, 2025
  6. Beyond Quantum Coherence: Sub-Femtosecond Lifetimes Underscore Classical Origins of Selectivity in Acid-Sensing Ion Channel 1
    C Vallée, Louie Slocombe, Max Winokan, Brendan James Howlin, Roger Lewis, Jim Al-Khalili, and Marco Sacchi
    ChemRxiv preprint, 2025
    In review, Nature Communications Chemistry
    DOI
  7. Conformational Dynamics of 8-Oxoguanine Mispairing Reveal a Mechanism of Polymerase λMisincorporation
    George Ferguson, Louie Slocombe, Max Winokan, Brendan James Howlin, and Marco Sacchi
    arXiv preprint arXiv:2509.15520, 2025
    In preparation for Physical Chemistry Chemical Physics
    arXiv

2024

  1. Measuring molecular complexity
    Louie Slocombe and Sara Imari Walker
    ACS Central Science, 2024
    DOI

2023

  1. Tautomerisation mechanisms in the Adenine-Thymine Nucleobase pair during DNA strand separation
    Benjamin King, Max Winokan, Paul Stevenson, Jim Al-Khalili, Louie Slocombe, and Marco Sacchi
    The journal of physical chemistry B, 2023
  2. Multiscale simulations reveal the role of PcrA helicase in protecting against spontaneous point mutations in DNA
    Max Winokan, Louie Slocombe, Jim Al-Khalili, and Marco Sacchi
    Scientific Reports, 2023
  3. How proton transfer impacts hachimoji DNA
    Harry Warman, Louie Slocombe, and Marco Sacchi
    RSC advances, 2023
  4. Quantum Tunnelling Effects in the Guanine-Thymine Wobble Misincorporation via Tautomerisation
    Louie Slocombe, Max Winokan, Jim Al-Khalili, and Marco Sacchi
    The Journal of Physical Chemistry Letters, 2023
    DOI

2022

  1. An open quantum systems approach to proton tunnelling in DNA
    Louie Slocombe, Marco Sacchi, and Jim Al-Khalili
    Communications Physics, 2022
  2. Proton Transfer During DNA Strand Separation as a Source of Mutagenic Guanine-Cytosine Tautomers
    Louie Slocombe, Max Winokan, Jim Al-Khalili, and Marco Sacchi
    Communications Chemistry, 2022
    DOI

2021

  1. Quantum biology: An update and perspective
    Youngchan Kim, Federico Bertagna, Edeline M D’souza, Derren J Heyes, Linus O Johannissen, Eveliny T Nery, Antonio Pantelias, Alejandro Sanchez-Pedreño Jimenez, Louie Slocombe, Michael G Spencer, and 1 more author
    Quantum Reports, 2021
  2. Quantum and classical effects in DNA point mutations: Watson–Crick tautomerism in AT and GC base pairs
    Louie Slocombe, Jim S Al-Khalili, and Marco Sacchi
    Physical Chemistry Chemical Physics, 2021
  3. Alkali metal adsorption on metal surfaces: new insights from new tools
    Arjun Raghavan, Louie Slocombe, Alexander Spreinat, David J Ward, William Allison, John Ellis, Andrew P Jardine, Marco Sacchi, and Nadav Avidor
    Physical Chemistry Chemical Physics, 2021

2018

  1. Electrical versus optical: Comparing methods for detecting terahertz radiation using neon lamps
    LL Slocombe and RA Lewis
    Journal of Infrared, Millimeter, and Terahertz Waves, 2018